By Christian Dani, Nathalie Billon (auth.), Michael E. Symonds (eds.)
This booklet is designed to supply a entire perception into present views and demanding situations in adipose tissue biology. In <i>Adipose Tissue Biology</i>, scientists and clinicians talk about adipocyte precursors, differentiation and development, brown and white adipose tissue, gender, irritation, nutritional and genetic determinants of fats mass, including evolutionary and developmental features of adiposity.
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Proc Natl Acad Sci USA 76:5138–5142 Pei H, Yao Y, Yang Y et al (2011) Krüppel-like factor KLF9 regulates PPARg transactivation at the middle stage of adipogenesis. Cell Death Differ 18(2):315–327 Qi CS, Surapureddi S, Zhu YJ et al (2003) Transcriptional coactivator PRIP, the peroxisome proliferator-activated receptor g (PPARg)- interacting protein, is required for PPARg-mediated adipogenesis. J Biol Chem 278:25281–25284 Ramji DP, Foka P (2002) CCAAT/enhancer-binding proteins: structure, function and regulation.
1997; Huypens et al. 2005; Alexandre et al. 2008; Fischer et al. 2010). Metformin effects on human adipocytes are likely to mediate through organic cationic transporter 1, which is induced during adipocyte differentiation (Moreno-Navarrete et al. 2011). 1 Epigenetic Factors in Adipogenesis Epigenetic regulation plays a critical role in several differentiation processes and possibly in adipocyte differentiation (D’Alessio et al. 2007). Recently, differentiation of 3T3-L1 cells was demonstrated to be associated with genome-wide epigenetic changes, as evidenced by the ratio of demethylation/methylation and furthermore maintenance of a static demethylated/methylated state, both of which depend on differentiation phase (Sakamoto et al.
Proc Natl Acad Sci USA 95:4333–4337 Klemm DJ, Leitner JW, Watson P et al (2001) Insulin-induced adipocyte differentiation. Activation of CREB rescues adipogenesis from the arrest caused by inhibition of prenylation. J Biol Chem 276:28430–28435 Klöting N, Berthold S, Kovacs P et al (2009) MicroRNA expression in human omental and subcutaneous adipose tissue. PLoS One 4(3):e4699 Konieczny SF, Emerson CP Jr (1984) 5-Azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: evidence for regulatory genes controlling determination.
Adipose Tissue Biology by Christian Dani, Nathalie Billon (auth.), Michael E. Symonds (eds.)