Alzheimer's disease : life course perspectives on risk - download pdf or read online

By Amy Borenstein, James Mortimer

ISBN-10: 0124171540

ISBN-13: 9780124171541

ISBN-10: 0128045388

ISBN-13: 9780128045381

Alzheimer's ailment: Lifecourse views on chance relief summarizes the starting to be physique of data at the distribution and motives of Alzheimer’s sickness (AD) in human populations, delivering the reader with wisdom on how we outline the affliction and what its possibility and protecting components are within the context of a life-course strategy.

At the realization of the e-book, the reader will comprehend why Alzheimer’s disorder most probably starts at belief, then progresses via early-life and grownup chance elements that finally impression the stability among pathologic insults within the mind and the power of the mind to switch ailment signs. unlike edited volumes that could have little solidarity, this e-book specializes in an built-in life-course method of the epidemiology of dementia, specifically, Alzheimer’s affliction.

  • Reviews the present technology surrounding Alzheimer’s disease
  • Provides a primer of foundational wisdom at the disease's epidemiology and biostatistics
  • Utilizes a life-course process, supplying a singular and built-in view of the evolution of this sickness from genes to mind reserve
  • Uses the ‘threshold model’—a concept first defined through Dr. Mortimer and extensively authorized today—which accommodates the assumption of possibility components for the pathology and expression of the sickness
  • Proposes that bettering mind future health via modifiable behaviors can hold up affliction onset until eventually a later age
  • Examines the way forward for prevention of Alzheimer’s illness, an issue of serious present interest

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Additional info for Alzheimer's disease : life course perspectives on risk reduction

Example text

For “MCI due to AD,” some experts have proposed the use of the term, “prodromal AD” to get at the concept of the continuum, rather than discrete categories of clinical diagnoses. , 2001, 1999). This small change in the operationalization of this criterion for MCI could increase misclassification between the diagnoses of MCI and dementia, which would increase the prevalence and incidence rates for MCI and reduce those for dementia (Morris, 2012). In a study examining this misclassification, Morris (2012) argues that the diagnosis of MCI might best be restricted to non-AD dementias, while those who have “MCI due to AD” be called “preclinical,” “prodromal,” or “early” AD.

As we shall discuss in Chapters 6 and 7, most current data come from studies conducted in one geographic region on one population subgroup, with a few of these individual studies enrolling multiple racial or ethnic groups. Studies that examine individuals in-person became the norm in prevalence and longitudinal studies of the incidence of and risk factors for dementia or AD in the late 1980s. ” In the first phase, the population was screened with a relatively short global cognitive test, such as the Mini-Mental Screening Examination.

Because diagnosis of AD requires an impairment of memory in addition to one or more deficits in other cognitive functions, it is necessary to assess multiple cognitive domains. Early in the disease course, at the MCI stage, it is possible for the only domain to be affected to be that of episodic memory. The following are the major domains that are usually assessed in evaluating whether an individual has AD (Weintraub, Wicklund, & Salmon, 2012). Episodic Memory A deficit in the ability to learn and remember new information (episodic memory) is frequently the earliest recognized sign of an Alzheimer process.

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Alzheimer's disease : life course perspectives on risk reduction by Amy Borenstein, James Mortimer


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